SMAD7:SMURF1 complex binds XPO1 (CRM1)

Stable Identifier
R-HSA-2167924
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD7:SMURF1 complex binds XPO1 (CRM1)
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SMAD7:SMURF1 complex binds to XPO1 (CRM1) through a nuclear export signal (NES) located in the C-terminus of SMURF1 (Tajima et al. 2003). Recombinant mouse Smad7 and recombinant human SMURF1 were used in this study.

Literature References
PubMed ID Title Journal Year
12519765 Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

Yoshida, M, Miyazono, K, Yoneda, Y, Tajima, Y, Shinomiya, K, Goto, K, Sekimoto, T, Imamura, T

J Biol Chem 2003
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Smad7:SMURF1 complex binds XPO1 (CRM1) (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-23)
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