Apolipoprotein A-I binds membrane-associated cholesterol and phospholipid to form a discoidal HDL particle

Stable Identifier
R-HSA-216756
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Extracellular apolipoprotein A-I interacts with phospholipid- and cholesterol-rich membrane patches formed through the action of ABCA1, binding these two lipids to form a discoidal (small nascent) HDL particle (HDL 3c - Kontush and Chapman 2006). The apoA-I molecules that accept lipids in this reaction appear to be different from the ones that activate ABCA1 at the plasma membrane (Hassan et al. 2007; Vedhachalam et al. 2007).

Literature References
PubMed ID Title Journal Year
17478755 ABCA1-induced cell surface binding sites for ApoA-I

Vedhachalam, C, Ghering, AB, Davidson, WS, Lund-Katz, S, Rothblat, GH, Phillips, MC

Arterioscler Thromb Vasc Biol 2007
Participants
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Orthologous Events
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