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4xPALM-C-p-2S-ABCA1 tetramer binds APOA1
Stable Identifier
R-HSA-216727
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
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Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein assembly (Homo sapiens)
HDL assembly (Homo sapiens)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Homo sapiens)
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ABCA1 associated with the plasma membrane binds extracellular apolipoprotein A-I (APOA1), forming a membrane-associated complex. The predominant form of ABCA1 is a heterotetramer (Denis et al. 2004), although studies in model systems in vitro are consistent with the hypothesis that the protein may also occur as a dimer (Trompier et al. 2006).
Literature References
PubMed ID
Title
Journal
Year
15280376
Characterization of oligomeric human ATP binding cassette transporter A1. Potential implications for determining the structure of nascent high density lipoprotein particles
Genest, J
,
Haidar, B
,
Denis, M
,
Bouvier, M
,
Marcil, M
,
Krimbou, L
J Biol Chem
2004
Participants
Input
4xPALM-C-p-2S-ABCA1 tetramer [plasma membrane]
(Homo sapiens)
APOA1(25-266) [extracellular region]
(Homo sapiens)
Output
4xPALM-C-p-2S-ABCA1 tetramer:APOA1 [plasma membrane]
(Homo sapiens)
Participates
as an event of
HDL assembly (Homo sapiens)
Orthologous Events
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Bos taurus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Canis familiaris)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Danio rerio)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Gallus gallus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Mus musculus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Rattus norvegicus)
4xPALM-C-p-2S-ABCA1 tetramer binds APOA1 (Sus scrofa)
Authored
D'Eustachio, P (2008-05-12)
Reviewed
Jassal, B (2008-06-13)
Created
D'Eustachio, P (2008-03-22)
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