Reactome | PDSS1,2 ligates FPP to IPPP

PDSS1,2 ligates FPP to IPPP

Stable Identifier

R-HSA-2162253

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

ReviewStatus

5/5

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The polyprenyl diphosphate synthase consists of a tetramer comprising two units of decaprenyl-diphosphate synthase subunit 1 (PDSS1) and two units of decaprenyl-diphosphate synthase subunit 2 (PDSS2). One or several Mg(2+) ions per PDSS1 subunit act as cofactors, although the exact number is unknown. The complex catalyses the combination of 2-trans,6-trans-farnesyl diphosphate (FPP) with seven isopentenyl diphosphate (IPPP) molecules to form the polyisoprenoid tail, all-trans-decaprenyl diphosphate (all-E-10PrP2) (Saiki et al. 2005, Tekle et al. 2008). IPPP and FPP are provided by cytosolic cholesterol biosynthesis. However, the means of transport of FPP and IPPP into mitochondria is unknown.

Literature References

PubMed ID	Title	Journal	Year
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T	J Biochem Biophys Methods	2008
16262699	Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans Kawamukai, M, Saiki, R, Kainou, T, Nagata, A, Matsuda, H	FEBS J	2005