Reactome | FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

Stable Identifier

R-HSA-2162253

Type

Reaction

Species

Homo sapiens

Compartment

mitochondrial matrix

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FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

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The polyprenyl diphosphate synthase consists of a tetramer comprising two units of decaprenyl-diphosphate synthase subunit 1 (PDSS1) and two units of decaprenyl-diphosphate synthase subunit 2 (PDSS2). It catalyses the combination of 2-trans,6-trans-farnesyl diphosphate (FPP) with isopentenyl diphosphate (IPPP) to form the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) (Saiki et al. 2005, Tekle et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T	J Biochem Biophys Methods	2008
16262699	Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans Kawamukai, M, Saiki, R, Kainou, T, Nagata, A, Matsuda, H	FEBS J	2005