Reactome | FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

Stable Identifier

R-HSA-2162253

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

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FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

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The polyprenyl diphosphate synthase consists of a tetramer comprising two units of decaprenyl-diphosphate synthase subunit 1 (PDSS1) and two units of decaprenyl-diphosphate synthase subunit 2 (PDSS2). It catalyses the combination of 2-trans,6-trans-farnesyl diphosphate (FPP) with isopentenyl diphosphate (IPPP) to form the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) (Saiki et al. 2005, Tekle et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
16262699	Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans Saiki, R, Nagata, A, Kainou, T, Matsuda, H, Kawamukai, M	FEBS J	2005
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Tekle, M, Turunen, M, Dallner, G, Chojnacki, T, Swiezewska, E	J Biochem Biophys Methods	2008