FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer

Stable Identifier
R-HSA-2162253
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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The polyprenyl diphosphate synthase consists of a tetramer comprising two units of decaprenyl-diphosphate synthase subunit 1 (PDSS1) and two units of decaprenyl-diphosphate synthase subunit 2 (PDSS2). It catalyses the combination of 2-trans,6-trans-farnesyl diphosphate (FPP) with isopentenyl diphosphate (IPPP) to form the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) (Saiki et al. 2005, Tekle et al. 2008).

Literature References
PubMed ID Title Journal Year
16262699 Characterization of solanesyl and decaprenyl diphosphate synthases in mice and humans

Saiki, R, Nagata, A, Kainou, T, Matsuda, H, Kawamukai, M

FEBS J 2005
17916383 Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells

Tekle, M, Turunen, M, Dallner, G, Chojnacki, T, Swiezewska, E

J Biochem Biophys Methods 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
all-trans-decaprenyl-diphosphate synthase activity of PDSS1/2 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created