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The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol
Stable Identifier
R-HSA-2162229
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
,
lysosomal lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glycosaminoglycan metabolism (Homo sapiens)
Hyaluronan metabolism (Homo sapiens)
Hyaluronan uptake and degradation (Homo sapiens)
The single sugars GlcA and GlcNAc translocate from the lysosome to the cytosol (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glucuronate and N-acetylglucosamine exit the lysosome into the cytosol, ready for reuse in GAG biosynthesis. The mechanism of translocation is unknown (for reviews see Stern 2004, Stern 2003).
Literature References
PubMed ID
Title
Journal
Year
14514708
Devising a pathway for hyaluronan catabolism: are we there yet?
Stern, R
Glycobiology
2003
15503855
Hyaluronan catabolism: a new metabolic pathway
Stern, R
Eur J Cell Biol
2004
Participants
Input
GlcA [lysosomal lumen]
GlcNAc [lysosomal lumen]
Output
GlcA [cytosol]
GlcNAc [cytosol]
Participates
as an event of
Hyaluronan uptake and degradation (Homo sapiens)
Authored
Jassal, B (2012-03-16)
Reviewed
D'Eustachio, P (2012-03-28)
Created
Jassal, B (2012-03-16)
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