GUSB tetramer hydrolyses (HA)2

Stable Identifier
R-HSA-2162227
Type
Reaction
Species
Homo sapiens
Compartment
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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from the HA tetrasaccharide (Oshima et al. 1987) resulting in the single sugars glucuronic acid and N-acetylglucosamine. These single sugars can exit the lysosome by an unknown mechanism. L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References
PubMed ID Title Journal Year
3468507 Cloning, sequencing, and expression of cDNA for human beta-glucuronidase

Kyle, JW, Gravel, RA, Powell, PP, Tropak, M, Sly, WS, Miller, RD, Grubb, JH, Oshima, A, Guise, KS, Hoffmann, JW

Proc Natl Acad Sci U S A 1987
11568288 A novel inhibitor of beta-glucuronidase: L-aspartic acid

Siegel, FL, Kreamer, BL, Gourley, GR

Pediatr Res 2001
Participants
Participates
Catalyst Activity

beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]

Orthologous Events
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