Reactome | GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

Stable Identifier

R-HSA-2162226

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

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GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from the HA disaccharide (Oshima et al. 1987) resulting in the single sugars glucuronic acid and N-acetylglucosamine. These single sugars can exit the lysosome by an unknown mechanism. L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11568288	A novel inhibitor of beta-glucuronidase: L-aspartic acid Kreamer, BL, Siegel, FL, Gourley, GR	Pediatr Res	2001
3468507	Cloning, sequencing, and expression of cDNA for human beta-glucuronidase Oshima, A, Kyle, JW, Miller, RD, Hoffmann, JW, Powell, PP, Grubb, JH, Sly, WS, Tropak, M, Guise, KS, Gravel, RA	Proc Natl Acad Sci U S A	1987