GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

Stable Identifier
R-HSA-2162226
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from the HA disaccharide (Oshima et al. 1987) resulting in the single sugars glucuronic acid and N-acetylglucosamine. These single sugars can exit the lysosome by an unknown mechanism. L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References
PubMed ID Title Journal Year
11568288 A novel inhibitor of beta-glucuronidase: L-aspartic acid

Kreamer, BL, Siegel, FL, Gourley, GR

Pediatr Res 2001
3468507 Cloning, sequencing, and expression of cDNA for human beta-glucuronidase

Oshima, A, Kyle, JW, Miller, RD, Hoffmann, JW, Powell, PP, Grubb, JH, Sly, WS, Tropak, M, Guise, KS, Gravel, RA

Proc Natl Acad Sci U S A 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created