Reactome | GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

Stable Identifier

R-HSA-2162226

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

GUSB tetramer hydrolyses GlcA-β1,3-GlcNAc

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The tetrameric lysosomal enzyme beta-glucuronidase hydrolyses glucuronate from the HA disaccharide (Oshima et al. 1987) resulting in the single sugars glucuronic acid and N-acetylglucosamine. These single sugars can exit the lysosome by an unknown mechanism. L-aspartic acid is an inhibitor of enzyme activity (Kreamer et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
3468507	Cloning, sequencing, and expression of cDNA for human beta-glucuronidase Kyle, JW, Gravel, RA, Powell, PP, Tropak, M, Sly, WS, Miller, RD, Grubb, JH, Oshima, A, Guise, KS, Hoffmann, JW	Proc Natl Acad Sci U S A	1987
11568288	A novel inhibitor of beta-glucuronidase: L-aspartic acid Siegel, FL, Kreamer, BL, Gourley, GR	Pediatr Res	2001