Reactome | COQ7 [mitochondrial inner membrane]

COQ7 [mitochondrial inner membrane]

Stable Identifier

R-HSA-2162218

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Ubiquinone biosynthesis protein COQ7 homolog, COQ7_HUMAN

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Metabolism of vitamins and cofactors (Homo sapiens)
  - Metabolism of cofactors (Homo sapiens)
    - Ubiquinol biosynthesis (Homo sapiens)
      - COQ3 methylates DHDB (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
      - COQ3 methylates DeMQ10H2 (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
      - COQ4 decarboxylates MHDB (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
      - COQ5 methylates MDMQ10H2 (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
      - COQ6 hydroxylates DHB (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
      - COQ7:COQ9 octamer hydroxylates DMQ10H2 (Homo sapiens)
        
        COQ3:COQ4:COQ5:COQ6:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 octamer [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ8A,B:COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:COQ9 [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)
        
        COQ7 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99807 COQ7

Gene Names

COQ7

Chain

transit peptide:1-35, chain:36-217

Reference Genes

BioGPS Gene:10229 COQ7

COSMIC (genes):COQ7 COQ7

CTD Gene:10229 COQ7

dbSNP Gene:10229 COQ7

ENSEMBL:ENSG00000167186 COQ7

HGNC:2244 COQ7

KEGG:hsa:10229 COQ7

Monarch:10229 COQ7

NCBI Gene:10229 COQ7

OMIM:601683 COQ7

UCSC:Q99807 COQ7

Reference Transcript

Other Identifiers

10229

11753575_at

16816408

209745_PM_at

209745_at

209746_PM_s_at

209746_s_at

210820_PM_x_at

210820_x_at

35385_at

3650803

3650804

3650805

3650806

3650807

3650808

3650809

3650810

3650811

3650812

3650813

3650814

3650816

3650817

3650818

3650819

3650820

3650821

3650822

3650823

3650824

3650825

43996_at

44848_at

59469_f_at

75727_at

7993608

A_23_P152322

A_24_P398972

GE79621

GO:0000122

GO:0003682

GO:0003824

GO:0004497

GO:0005515

GO:0005634

GO:0005694

GO:0005739

GO:0005743

GO:0006355

GO:0006744

GO:0008340

GO:0008682

GO:0010468

GO:0016020

GO:0016491

GO:0016709

GO:0031314

GO:0043226

GO:0045944

GO:0046872

GO:0110142

GO:0160224

GO:2000377

HMNXSV003004248

Hs.157113.0.S2_3p_at

ILMN_1689070

PH_hs_0009500

PH_hs_0040338

TC16000209.hg

g3811294_3p_a_at

Participates

as a component of

COQ7:Fe2+ [mitochondrial inner membrane] (Homo sapiens)

Inferred To

coq7 [mitochondrial inner membrane] (Danio rerio)

coq7 [mitochondrial inner membrane] (Dictyostelium discoideum)

coq7 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

coq7 [mitochondrial inner membrane] (Xenopus tropicalis)

clk-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

COQ7 [mitochondrial inner membrane] (Bos taurus)

COQ7 [mitochondrial inner membrane] (Canis familiaris)

COQ7 [mitochondrial inner membrane] (Gallus gallus)

COQ7 [mitochondrial inner membrane] (Sus scrofa)

Coq7 [mitochondrial inner membrane] (Drosophila melanogaster)

Coq7 [mitochondrial inner membrane] (Mus musculus)

Coq7 [mitochondrial inner membrane] (Rattus norvegicus)

CAT5 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

XP_047289450.1, NP_001357423.1, NP_001357421.1, NP_001357422.1, NP_057222.2, XP_047289451.1, XP_047289452.1, NP_001177912.1

ENSEMBL

ENSG00000167186, ENST00000568985, ENSP00000456734, ENSP00000322316, ENSP00000442923, ENST00000321998, ENST00000544894

OpenTargets

ENSG00000167186

IntEnz

1.14.13.253

GeneCards

COQ7

HPA

ENSG00000167186-COQ7

PRO

Q99807

Pharos - Targets

Q99807

Orphanet

COQ7

HMDB Protein

HMDBP01736

PDB

7SSP, 7SSS