Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonic acid with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE).
Kenyon, V, Wecksler, AT, Deschamps, JD, Holman, TR
Jörnvall, H, Rådmark, O, Izumi, T, Samuelsson, B
Bursztyn-Pettegrew, H, Chow, J, Baecker, P, Grunberger, D, Kühn, H, Barnett, J, Sigal, E, Chan, H, Nguyen, B
Liu, J, Traag, J, Zhau, HE, Tang, DG, Shen, J, Klein, RD, Maldonado, CJ, Tang, S, Chung, LW, Yang, P, Newman, RA, Chandra, D, Bhatia, B, Fischer, SM, Chopra, D
Kumlin, M, Nilsson, G, Brunnström, A, Harvima, I, Dahlén, B, Backman, L, Gulliksson, M, Claesson, HE, Johannesson, M
arachidonate 15-lipoxygenase activity of ALOX15/15B [cytosol]
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