Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonic acid with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE).
Izumi, T, Rådmark, O, Jörnvall, H, Samuelsson, B
Wecksler, AT, Kenyon, V, Deschamps, JD, Holman, TR
Kühn, H, Barnett, J, Grunberger, D, Baecker, P, Chow, J, Nguyen, B, Bursztyn-Pettegrew, H, Chan, H, Sigal, E
Tang, S, Bhatia, B, Maldonado, CJ, Yang, P, Newman, RA, Liu, J, Chandra, D, Traag, J, Klein, RD, Fischer, SM, Chopra, D, Shen, J, Zhau, HE, Chung, LW, Tang, DG
Gulliksson, M, Brunnström, A, Johannesson, M, Backman, L, Nilsson, G, Harvima, I, Dahlén, B, Kumlin, M, Claesson, HE
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