Reactome | Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B

Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B

Stable Identifier

R-HSA-2162002

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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Arachidonic acid is oxidised to 15S-HpETE by ALOX15/15B

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Arachidonate 15-lipoxygenase (ALOX15) (Gulliksson et al. 2007, Kuhn et al. 1993, Izumi et al. 1991) and arachidonate 15-lipoxygenase B (ALOX15B) (Tang et al. 2002, Wecksler et al. 2008) are lipid peroxidising enzymes mainly expressed in airway epithelial cells, eosinophils, reticulocytes and in macrophages. They insert molecular oxygen at C-6 from the omega-end of arachidonic acid with formation of the unstable intermediate 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) which can be further converted, enzymatically or non-enzymatically, to 15S-hydroxyeicosatetraenoic acid (15S-HETE).

Literature References

PubMed ID	Title	Journal	Year
1662607	Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes Izumi, T, Rådmark, O, Jörnvall, H, Samuelsson, B	Eur J Biochem	1991
18570379	Substrate specificity changes for human reticulocyte and epithelial 15-lipoxygenases reveal allosteric product regulation Wecksler, AT, Kenyon, V, Deschamps, JD, Holman, TR	Biochemistry	2008
8334154	Overexpression, purification and characterization of human recombinant 15-lipoxygenase Kühn, H, Barnett, J, Grunberger, D, Baecker, P, Chow, J, Nguyen, B, Bursztyn-Pettegrew, H, Chan, H, Sigal, E	Biochim Biophys Acta	1993
11839751	Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells Tang, S, Bhatia, B, Maldonado, CJ, Yang, P, Newman, RA, Liu, J, Chandra, D, Traag, J, Klein, RD, Fischer, SM, Chopra, D, Shen, J, Zhau, HE, Chung, LW, Tang, DG	J Biol Chem	2002
17662651	Expression of 15-lipoxygenase type-1 in human mast cells Gulliksson, M, Brunnström, A, Johannesson, M, Backman, L, Nilsson, G, Harvima, I, Dahlén, B, Kumlin, M, Claesson, HE	Biochim Biophys Acta	2007