12S-HpETE is reduced to 12S-HETE by GPX1/2/4

Stable Identifier
R-HSA-2161999
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Glutathione peroxidase 1 (GPX1) (Bryant et al. 1982, Sutherland et al. 2001), 2 (GPX2) (Chu et al. 1993), and 4 (Bryant et al. 1982, Sutherland et al. 2001) are involved in converting 12S-hydroperoxy-eicosatetraenoic acid (12S-HpETE) to 12S-hydro-eicosatetraenoic acid (12S-HETE). GPXs are selenoenzymes that are responsible for reducing the cellular peroxide. Cellular GPXs compete with hepoxilins A3 (HXA3) synthase for 12S-HpETE as substrate either to produce 12S-HETE or to convert to HXA3, respectively.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX1/2/4 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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Created
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