Reactome | 5,6-EET is hydrolysed to 5,6-DHET by EPHX2

5,6-EET is hydrolysed to 5,6-DHET by EPHX2

Stable Identifier

R-HSA-2161961

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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5,6-EET is hydrolysed to 5,6-DHET by EPHX2

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Epoxide hydrolase 2 (EPHX2) hydrolyses 5,6-epoxyeicosatrienoate (5,6-EET) to 5,6-dihydroxyeicosatrienoate (5,6-DHET) (Werner et al. 2002; Gomez et al. 2004). The majority of the EET biological activities are diminished by this hydrolysis.

Literature References

PubMed ID	Title	Journal	Year
12468260	Characterization and identification of cytochrome P450 metabolites of arachidonic acid released by human peritoneal macrophages obtained from the pouch of Douglas Deppert, WR, Schaefer, WR, Zahradnik, HP, Schweer, H, Karck, U, Werner, K	Prostaglandins Leukot Essent Fatty Acids	2002
15096040	Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis Hammock, BD, Morisseau, C, Christianson, DW, Gomez, GA	Biochemistry	2004