Reactome | Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2

Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2

Stable Identifier

R-HSA-2161951

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

Synonyms

(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => (15R)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)

ReviewStatus

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Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2

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Aspirin acetylates the cyclooxygenase, prostaglandin G/H synthase 2 (PTGS2) aka COX2. The acetylated PTGS2 triggers the formation of 15R-hydroxyeicosatetraenoate (15R-HETE) from arachidonate (Claria & Serhan 1995).

Literature References

PubMed ID	Title	Journal	Year
7568157	Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions Clària, J, Serhan, CN	Proc Natl Acad Sci U S A	1995