Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2

Stable Identifier
R-HSA-2161951
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Aspirin acetylates the cyclooxygenase, prostaglandin G/H synthase 2 (PTGS2) aka COX2. The acetylated PTGS2 triggers the formation of 15R-hydroxyeicosatetraenoic acid (15R-HETE) from arachidonic acid (Claria & Serhan 1995).

Literature References
PubMed ID Title Journal Year
7568157 Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions

Clària, J, Serhan, CN

Proc Natl Acad Sci U S A 1995
Participants
Input
Output
Participates
as an event of
Catalyst Activity

arachidonate 15-lipoxygenase activity of Ac-PTGS2 dimer [endoplasmic reticulum membrane]

Physical Entity
Ac-PTGS2 dimer [endoplasmic reticulum membrane] (Homo sapiens)
Activity
arachidonate 15-lipoxygenase activity (GO:0050473)
Orthologous Events
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Bos taurus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Canis familiaris)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Danio rerio)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Gallus gallus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Mus musculus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Rattus norvegicus)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Sus scrofa)
Arachidonic acid is oxidised to 15R-HETE by Acetyl-PTGS2 (Xenopus tropicalis)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
Cite Us!