Arachidonate is oxidised to 12R-HpETE by ALOX12B

Stable Identifier
R-HSA-2161950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 => (12R)-hydroperoxy-(5Z,8Z,10E,14Z)-eicosatetraenoate
ReviewStatus
5/5
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Arachidonate is oxidised to 12R-HpETE by ALOX12B
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The arachidonate 12-lipoxygenase, 12R-type (ALOX12B) oxidises arachidonate to 12R-hydroperoxy-eicosatetraenoate (12R-HpETE) (Boeglin et al. 1998).
Literature References
PubMed ID Title Journal Year
9618483 A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression

Boeglin, WE, Kim, RB, Brash, AR

Proc Natl Acad Sci U S A 1998
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Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12B:Fe2+ [cytosol]

Physical Entity
ALOX12B:Fe2+ [cytosol] (Homo sapiens)
Activity
arachidonate 12(S)-lipoxygenase activity (GO:0004052)
Orthologous Events
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Bos taurus)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Canis familiaris)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Danio rerio)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Dictyostelium discoideum)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Gallus gallus)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Mus musculus)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Rattus norvegicus)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Sus scrofa)
Arachidonate is oxidised to 12R-HpETE by ALOX12B (Xenopus tropicalis)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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