HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH

Stable Identifier
R-HSA-2161949
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
10-hydroxy-(11S,12S)-epoxy- (5Z,8Z,14Z)-eicosatrienoate + H2O => (10,11S,12R)-trihydroxy-(5Z,8Z,14Z)-eicosatrienoate
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HXA3/B3 is hydrolysed to TrXA3/B3 by HXEH
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The epoxy moiety of hepoxilin A3 (HXA3) and B3 (HXB3) is labile and can be hydrolysed either by a hepoxilin specific epoxide hydrolase (HXEH) or in acidic aqueous solution to form the corresponding diol metabolites trioxilin A3 (TrXA3) and B3 (TrXB3) (Anton et al. 1995, Anton et al. 1998, Pace-Asciak et al. 1983, Pace-Asciak & Lee 1989).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hepoxilin-epoxide hydrolase activity of HXEH [cytosol]

Physical Entity
HXEH [cytosol] (Homo sapiens)
Activity
hepoxilin-epoxide hydrolase activity (GO:0047977)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
Cite Us!