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Arachidonic acid is converted to 12-oxoETE by ALOX12
Stable Identifier
R-HSA-2161948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Homo sapiens)
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the formation of 12-oxo-eicosatetraenoic acid (12-oxoETE) from arachidonic acid. This conversion has been observed when normal human epidermis is exposed to arachidonic acid and with the purified recombinant enzyme in vitro (Anton & Vila 2000).
Literature References
PubMed ID
Title
Journal
Year
10692117
Stereoselective biosynthesis of hepoxilin B3 in human epidermis
Antón, R
,
Vila, L
J Invest Dermatol
2000
Participants
Input
AA [cytosol]
Output
12-oxoETE [cytosol]
Participates
as an event of
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Catalyst Activity
arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]
Physical Entity
ALOX12:Fe2+ [cytosol]
(Homo sapiens)
Activity
arachidonate 12(S)-lipoxygenase activity (GO:0004052)
Orthologous Events
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Bos taurus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Canis familiaris)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Danio rerio)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Mus musculus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Sus scrofa)
Authored
Williams, MG (2012-02-24)
Reviewed
Rush, MG (2012-11-10)
Created
Williams, MG (2012-03-14)
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