Arachidonic acid is converted to 12-oxoETE by ALOX12

Stable Identifier
R-HSA-2161948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the formation of 12-oxo-eicosatetraenoic acid (12-oxoETE) from arachidonic acid. This conversion has been observed when normal human epidermis is exposed to arachidonic acid and with the purified recombinant enzyme in vitro (Anton & Vila 2000).

Literature References
PubMed ID Title Journal Year
10692117 Stereoselective biosynthesis of hepoxilin B3 in human epidermis

Antón, R, Vila, L

J Invest Dermatol 2000
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Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]

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