Arachidonate is converted to 12-oxoETE by ALOX12

Stable Identifier
R-HSA-2161948
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Arachidonate is converted to 12-oxoETE by ALOX12
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) catalyses the formation of 12-oxo-eicosatetraenoic acid (12-oxoETE) from arachidonic acid. This conversion has been observed when normal human epidermis is exposed to arachidonate and with the purified recombinant enzyme in vitro (Anton & Vila 2000).
Literature References
PubMed ID Title Journal Year
10692117 Stereoselective biosynthesis of hepoxilin B3 in human epidermis

Antón, R, Vila, L

J Invest Dermatol 2000
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Output
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as an event of
Catalyst Activity

arachidonate 12(S)-lipoxygenase activity of ALOX12:Fe2+ [cytosol]

Physical Entity
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Activity
arachidonate 12(S)-lipoxygenase activity (GO:0004052)
Orthologous Events
Arachidonate is converted to 12-oxoETE by ALOX12 (Bos taurus)
Arachidonate is converted to 12-oxoETE by ALOX12 (Canis familiaris)
Arachidonate is converted to 12-oxoETE by ALOX12 (Danio rerio)
Arachidonate is converted to 12-oxoETE by ALOX12 (Dictyostelium discoideum)
Arachidonate is converted to 12-oxoETE by ALOX12 (Mus musculus)
Arachidonate is converted to 12-oxoETE by ALOX12 (Rattus norvegicus)
Arachidonate is converted to 12-oxoETE by ALOX12 (Sus scrofa)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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