Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)

Stable Identifier
R-HSA-2161795
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
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Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)
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Cytochrome P450s 1A1 (CYP1A1), 1A2 (CYP1A2), and 1B1 (CYP1B1) convert arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids (16-, 17-, and 18-HETEs) (Choudhary et al. 2004).

Literature References
PubMed ID Title Journal Year
15258110 Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1

Choudhary, D, Jansson, I, Stoilov, I, Sarfarazi, M, Schenkman, JB

Drug Metab Dispos 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
monooxygenase activity of CYP(1) [endoplasmic reticulum membrane]
Physical Entity
CYP(1) [endoplasmic reticulum membrane]
Activity
monooxygenase activity (0004497)
Orthologous Events
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Bos taurus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Canis familiaris)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Danio rerio)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Gallus gallus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Mus musculus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Rattus norvegicus)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Sus scrofa)
Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1) (Xenopus tropicalis)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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