Arachidonic acid is converted to HXA3/B3 by ALOX12

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Arachidonate 12-lipoxygenase, 12S-type (ALOX12) converts arachidonic acid to both hepoxilin A3 (HXA3) and B3 (HXB3). They both incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety with HXA3 having a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10 (Sutherland et al. 2001, Nigam et al. 2004).

Literature References
PubMed ID Title Journal Year
11115402 Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism

Schewe, T, Shankaranarayanan, P, Nigam, S, Sutherland, M

Biochem J 2001
15123652 The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity

Ciccoli, R, Haeggström, JZ, Schwarz, K, Patabhiraman, S, Nigam, S, Kühn, H, Ishdorj, G, Petrucev, B

J Biol Chem 2004
Catalyst Activity

hepoxilin A3 synthase activity of ALOX12:Fe2+ [cytosol]

Orthologous Events
Cite Us!