Arachidonic acid is converted to HXA3/B3 by ALOX12

Stable Identifier
R-HSA-2161794
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Arachidonate 12-lipoxygenase, 12S-type (ALOX12) converts arachidonic acid to both hepoxilin A3 (HXA3) and B3 (HXB3). They both incorporate an epoxide across the C-11 and C-12 double bond, as well as an additional hydroxyl moiety with HXA3 having a C-8 hydroxyl, whereas the HXB3 hydroxyl occurs at C-10 (Sutherland et al. 2001, Nigam et al. 2004).

Literature References
PubMed ID Title Journal Year
15123652 The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A3 synthase activity

Nigam, S, Patabhiraman, S, Ciccoli, R, Ishdorj, G, Schwarz, K, Petrucev, B, Kühn, H, Haeggström, JZ

J Biol Chem 2004
11115402 Evidence for the presence of phospholipid hydroperoxide glutathione peroxidase in human platelets: implications for its involvement in the regulatory network of the 12-lipoxygenase pathway of arachidonic acid metabolism

Sutherland, M, Shankaranarayanan, P, Schewe, T, Nigam, S

Biochem J 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hepoxilin A3 synthase activity of ALOX12:Fe2+ [cytosol]
Physical Entity
Activity
Orthologous Events
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