15S-HpETE is reduced to 15S-HETE by GPX1/2/4

Stable Identifier
R-HSA-2161791
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
(15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + 2 glutathione => (15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate + glutathione disulfide + H2O
ReviewStatus
5/5
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15S-HpETE is reduced to 15S-HETE by GPX1/2/4
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Glutathione peroxidases (GPXs) in human platelets (either GPX1, GPX2, or GPX4 are present in the cytosol) are involved in reducing 15S-hydroperoxyeicosatetraenoic acid (15S-HpETE) to 15S-hydroxyeicosatetraenoic acid (15S-HETE) (Hill et al. 1989).
Literature References
PubMed ID Title Journal Year
2501828 Role of glutathione and glutathione peroxidase in human platelet arachidonic acid metabolism

Hill, TD, Rao, GH, White, JG

Prostaglandins 1989
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glutathione peroxidase activity of GPX1/2/4 [cytosol]

Physical Entity
GPX1/2/4 [cytosol] (Homo sapiens)
Activity
glutathione peroxidase activity (GO:0004602)
Orthologous Events
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Canis familiaris)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Mus musculus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Rattus norvegicus)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Sus scrofa)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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