LXA4 is oxidised to 15k-LXA4 by HPGD

Stable Identifier
R-HSA-2161779
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

15-Hydroxyprostaglandin dehydrogenase (HPGD) converts lipoxin A4 (LXA4) to 15-oxo lipoxin A4 aka 15-keto-LXA4 (15k-LXA4) (Clish et al. 2000).

Literature References
PubMed ID Title Journal Year
10837478 Oxidoreductases in lipoxin A4 metabolic inactivation: a novel role for 15-oxoprostaglandin 13-reductase/leukotriene B4 12-hydroxydehydrogenase in inflammation

Clish, CB, Levy, BD, Chiang, N, Tai, HH, Serhan, CN

J Biol Chem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!