5S-HETE is oxidised to 5-oxoETE by 5-HEDH

Stable Identifier
R-HSA-2161776
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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5S-HETE is oxidised to 5-oxoETE by 5-HEDH
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Current literature suggests that 5S-hydroxy-eicosatetraenoic acid (5S-HETE) itself does not appear to play a significant role in biological signalling. However, it can be further oxidised by a 5-hydroxy-eicosatetraenoic acid dehydrogenase (5-HEDH) to form the bioactive 5-oxo-eicosatetraenoic acid (5-oxoETE, also known as 5-KETE. While the gene has not yet been cloned, the biophysical properties of the human enzyme have been well characterised (Powell et al. 1992).
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Catalyst Activity

5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity of 5-HEDH [cytosol]

Physical Entity
5-HEDH [cytosol] (Homo sapiens)
Activity
5(S)-hydroxyeicosatetraenoic acid dehydrogenase activity (GO:0097265)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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