PGH2 is isomerised to PGD2 by HPGDS

Stable Identifier
Reaction [transition]
Homo sapiens
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Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, HPGDS with GSH promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Jowsey et al. 2001, Inoue et al. 2003).

Literature References
PubMed ID Title Journal Year
11672424 Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases

Thomson, AM, Hayes, JD, Murdock, PR, Meyer, DJ, Moore, GB, Jowsey, IR, Murphy, GJ, Flanagan, JU, Smith, SA

Biochem J 2001
12627223 Mechanism of metal activation of human hematopoietic prostaglandin D synthase

Irikura, D, Kai, Y, Miyano, M, Matsumura, H, Urade, Y, Yamamoto, M, Kinugasa, S, Inoue, T, Okazaki, N, Uodome, N, Kumasaka, T

Nat Struct Biol 2003
Catalyst Activity

prostaglandin-D synthase activity of HPGDS dimer [cytosol]

Orthologous Events
Cross References
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