Reactome | PGH2 is isomerised to PGD2 by HPGDS

PGH2 is isomerised to PGD2 by HPGDS

Stable Identifier

R-HSA-2161701

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

prostaglandin H2 => prostaglandin D2

ReviewStatus

5/5

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Prostaglandin D2 (PGD2) is a structural isomer of prostaglandin E2 (PGE2). There is a 9-keto and 11-hydroxy group on PGE2 with these substituents reversed on PGD2. PGD2 is formed by two evolutionarily distinct, but functionally convergent, prostaglandin D synthases: lipocalin-type prostaglandin-D synthase aka Prostaglandin-H2 D-isomerase (PTDGS) and hematopoietic prostaglandin D synthase (HPGDS). One of the main differences between these two proteins is that HPGDS requires glutathione (GSH) for catalysis while PTDGS can function without this cofactor. Here, HPGDS with GSH promotes the isomerisation of prostaglandin H2 (PGH2) to prostaglandin D2 (PGD2) (Jowsey et al. 2001, Inoue et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11672424	Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases Jowsey, IR, Thomson, AM, Flanagan, JU, Murdock, PR, Moore, GB, Meyer, DJ, Murphy, GJ, Smith, SA, Hayes, JD	Biochem J	2001
12627223	Mechanism of metal activation of human hematopoietic prostaglandin D synthase Inoue, T, Irikura, D, Okazaki, N, Kinugasa, S, Matsumura, H, Uodome, N, Yamamoto, M, Kumasaka, T, Miyano, M, Kai, Y, Urade, Y	Nat Struct Biol	2003