15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1

Stable Identifier
R-HSA-2161692
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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15k-PGE2/F2a is reduced to dhk-PGE2/F2a by PTGR1
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Prostaglandin reductase 2 (PTGR2) is a 13-prostaglandin reductase which metabolises eicosanoids by catalysing NADH/NADPH-dependant double bond reduction in 15-keto-prostaglandin E2 (15k-PGE2) and F2alpha (15k-PGF2a) to produce 13,14-dihydro-15-keto-prostaglandin E2 (dhk-PGE2) and F2alpha (dhk-PGF2a) respectively (Wu et al. 2008). This has been inferred from the reaction event in mice involving prostaglandin reductase 2 (Ptgr2) (Chou et al. 2007).
Literature References
PubMed ID Title Journal Year
19000823 Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2

Ko, TP, Wang, AH, Guo, RT, Wu, YH, Hu, SM, Chuang, LM

Structure 2008
17449869 Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation

Wang, AH, Chang, ZF, Lawson, JA, Chuang, LM, Chou, WL, FitzGerald, GA, Chou, CC

J Biol Chem 2007
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Catalyst Activity

15-oxoprostaglandin 13-oxidase [NAD(P)+] activity of PTGR2 [cytosol]

Physical Entity
PTGR2 [cytosol] (Homo sapiens)
Activity
15-oxoprostaglandin 13-oxidase [NAD(P)+] activity (GO:0047522)
Inferred From
15k-PGE2/F2a is reduced to dhk-PGE2/F2a by Ptgr2 (Mus musculus)
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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