PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD

Stable Identifier
R-HSA-2161662
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
15-Hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Cho et al. 2006). This reaction is inferred from rabbits (Bergholte & Okita 1986).
Literature References
PubMed ID Title Journal Year
16828555 Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2

Tai, HH, Zhan, CG, Gao, D, Huang, L, Cho, H, Hamza, A

Bioorg Med Chem 2006
3954355 Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits

Okita, RT, Bergholte, JM

Arch Biochem Biophys 1986
Participants
Input
Output
Participates
as an event of
Catalyst Activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]

Physical Entity
HPGD dimer [cytosol] (Homo sapiens)
Activity
15-hydroxyprostaglandin dehydrogenase (NAD+) activity (GO:0016404)
Inferred From
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Oryctolagus cuniculus)
Cross References
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
Cite Us!