PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD

Stable Identifier
R-HSA-2161662
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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15-Hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Cho et al. 2006). This reaction is inferred from rabbits (Bergholte & Okita 1986).

Literature References
PubMed ID Title Journal Year
3954355 Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits

Bergholte, JM, Okita, RT

Arch Biochem Biophys 1986
16828555 Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2

Cho, H, Huang, L, Hamza, A, Gao, D, Zhan, CG, Tai, HH

Bioorg Med Chem 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]
Physical Entity
Activity
Inferred From
Cross References
Rhea
Authored
Reviewed
Created
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