PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD

Stable Identifier
R-HSA-2161662
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD
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15-Hydroxyprostaglandin dehydrogenase (HPGD) oxidises prostaglandins D2 (PGD2), E2 (PGE2), and F2alpha (PGF2a) to 15-keto-prostaglandin D2 (15k-PGD2), E2 (15k-PGE2), and F2alpha (15k-PGF2a) respectively (Cho et al. 2006). This reaction is inferred from rabbits (Bergholte & Okita 1986).
Literature References
PubMed ID Title Journal Year
16828555 Role of glutamine 148 of human 15-hydroxyprostaglandin dehydrogenase in catalytic oxidation of prostaglandin E2

Cho, H, Huang, L, Hamza, A, Gao, D, Zhan, CG, Tai, HH

Bioorg Med Chem 2006
3954355 Isolation and properties of lung 15-hydroxyprostaglandin dehydrogenase from pregnant rabbits

Bergholte, JM, Okita, RT

Arch Biochem Biophys 1986
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Catalyst Activity

15-hydroxyprostaglandin dehydrogenase (NAD+) activity of HPGD dimer [cytosol]

Physical Entity
HPGD dimer [cytosol] (Homo sapiens)
Activity
15-hydroxyprostaglandin dehydrogenase (NAD+) activity (GO:0016404)
Inferred From
PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD (Oryctolagus cuniculus)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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