Reactome | PGH2 is isomerised to PGE2 by PTGES

PGH2 is isomerised to PGE2 by PTGES

Stable Identifier

R-HSA-2161660

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

ReviewStatus

5/5

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Prostaglandin E synthase (PTGES) requires glutathione (GSH) as an essential cofactor for its enzymatic activity, and together they isomerise prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2) (Jegerschold et al. 2008). After PGH2 has been produced by the prostaglandin G/H synthases (PTGS1 and 2) on the lumenal side of the endoplasmic reticulum, it diffuses through the membrane to the active site of PTGES located on the cytoplasmic side.

Literature References

PubMed ID	Title	Journal	Year
18682561	Structural basis for induced formation of the inflammatory mediator prostaglandin E2 Gheorghe, KR, Morgenstern, R, Jakobsson, PJ, Mitsuoka, K, Pawelzik, SC, Jegerschöld, C, Bhakat, P, Purhonen, P, Hebert, H, Gyobu, N	Proc Natl Acad Sci U S A	2008