Reactome | PGE2 is dehydrated to PGA2

PGE2 is dehydrated to PGA2

Stable Identifier

R-HSA-2161659

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cyclopentenone prostaglandins comprise a family of molecules that are formed by dehydration of hydroxyl moieties in prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2). Dehydration of PGE2 leads to prostaglandin A2 (PGA2) (Hamberg & Samuelsson B 1966, Amin 1989).

Literature References

PubMed ID	Title	Journal	Year
2717650	Simultaneous determination of prostaglandins (PG) E2, A2 and B2 and stability studies of PGE2 in pharmaceutical preparations by ion-pair reversed phase HPLC Amin, M	Pharm Acta Helv	1989
5903721	Prostaglandins in human seminal plasma. Prostaglandins and related factors 46 Hamberg, M, Samuelsson, B	J Biol Chem	1966

Participants

Input

PGE2 [cytosol]

Output

Participates

as an event of

Synthesis of Prostaglandins (PG) and Thromboxanes (TX) (Homo sapiens)

Cross References

Rhea

50537

Authored

Williams, MG (2012-02-24)

Reviewed

Rush, MG (2012-11-10)

Created

Williams, MG (2012-03-14)

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