PGE2 is converted to PGF2a by CBR1

Stable Identifier
R-HSA-2161651
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
H(+) + NADPH + prostaglandin E2 => NADP(+) + prostaglandin F2alpha
ReviewStatus
5/5
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PGE2 is converted to PGF2a by CBR1
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Carbonyl reductase (CBR1) aka prostaglandin 9-keto reductase inactivates prostaglandin E2 (PGE2) by converting it to prostaglandin F2alpha (PGF2a) (Wermuth 1981, Miura et al. 2008).
Literature References
Participants
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Output
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as an event of
Catalyst Activity

prostaglandin E2 9-reductase activity of CBR1 [cytosol]

Physical Entity
CBR1 [cytosol] (Homo sapiens)
Activity
prostaglandin E2 9-reductase activity (GO:0050221)
Orthologous Events
PGE2 is converted to PGF2a by CBR1 (Bos taurus)
PGE2 is converted to PGF2a by CBR1 (Canis familiaris)
PGE2 is converted to PGF2a by CBR1 (Danio rerio)
PGE2 is converted to PGF2a by CBR1 (Gallus gallus)
PGE2 is converted to PGF2a by CBR1 (Mus musculus)
PGE2 is converted to PGF2a by CBR1 (Rattus norvegicus)
PGE2 is converted to PGF2a by CBR1 (Sus scrofa)
PGE2 is converted to PGF2a by CBR1 (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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