PGI2 is hydrolysed to 6k-PGF1a

Stable Identifier
R-HSA-2161619
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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PGI2 is hydrolysed to 6k-PGF1a
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ring in prostaglandin I2 (PGI2) aka prostacyclin is highly labile and rapidly hydolyses to form the stable but biologically inactive 6-keto-prostaglandin F1alpha (6k-PGF1a) (Wada et al. 2004). PGI2 and 6k-PGF1a are often used interchangeably in the literature.
Literature References
PubMed ID Title Journal Year
15115769 Purification and characterization of recombinant human prostacyclin synthase

Shimonishi, M, Yokoyama, C, Imai, Y, Ullrich, V, Nakamura, M, Hatae, T, Tanabe, T, Wada, M

J Biochem 2004
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Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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