PGH2 is degraded to 12S-HHT and MDA by TBXAS1

Stable Identifier
R-HSA-2161613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Thromboxane synthase (TBXAS1) aka CYP5A1 facilitates rearrangement of the PGH2 endoperoxide bridge by a complementary mechanism to prostacyclin synthase, interacting with the C-9 oxygen to promote endoperoxide bond cleavage. The C-11 oxygen radical initiates intramolecular rearrangement, resulting in either the formation of thromboxane A2 (TXA2) or 12-hydroxyheptadecatrienoic acid (12S-HHT) and malonaldehyde (MDA) (Wang et al. 2001).

Literature References
PubMed ID Title Journal Year
11297515 Substrate binding is the rate-limiting step in thromboxane synthase catalysis

Wang, LH, Tsai, AL, Hsu, PY

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
12-hydroxyheptadecatrienoic acid synthase activity of TBXAS1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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