PGH2 is degraded to 12S-HHT and MDA by TBXAS1

Stable Identifier
R-HSA-2161613
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, endoplasmic reticulum lumen
Synonyms
prostaglandin H2 => (12S)-hydroxy-(5Z,8E,10E)-heptadecatrienoate + malonaldehyde
ReviewStatus
5/5
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PGH2 is degraded to 12S-HHT and MDA by TBXAS1
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Thromboxane synthase (TBXAS1) aka CYP5A1 facilitates rearrangement of the PGH2 endoperoxide bridge by a complementary mechanism to prostacyclin synthase, interacting with the C-9 oxygen to promote endoperoxide bond cleavage. The C-11 oxygen radical initiates intramolecular rearrangement, resulting in either the formation of thromboxane A2 (TXA2) or 12-hydroxyheptadecatrienoic acid (12S-HHT) and malonaldehyde (MDA) (Wang et al. 2001).
Literature References
PubMed ID Title Journal Year
11297515 Substrate binding is the rate-limiting step in thromboxane synthase catalysis

Tsai, AL, Wang, LH, Hsu, PY

J Biol Chem 2001
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Catalyst Activity

12-hydroxyheptadecatrienoic acid synthase activity of TBXAS1 [endoplasmic reticulum membrane]

Physical Entity
TBXAS1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
12-hydroxyheptadecatrienoic acid synthase activity (GO:0036134)
Orthologous Events
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Bos taurus)
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Canis familiaris)
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Gallus gallus)
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Mus musculus)
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Rattus norvegicus)
PGH2 is degraded to 12S-HHT and MDA by TBXAS1 (Sus scrofa)
Cross References
RHEA
Rhea
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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