PGH2 is reduced to PGF2a by FAM213B

Stable Identifier
R-HSA-2161612
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
thioredoxin-dithiol + prostaglandin H2 => thioredoxin-disulfide + prostaglandin F2alpha
ReviewStatus
5/5
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PGH2 is reduced to PGF2a by FAM213B
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Prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TXN) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011). This reaction has been inferred from an event in mice. An additional way of achieving this reaction involves the protein aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS.
Literature References
PubMed ID Title Journal Year
18006499 Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily

Daiyasu, H, Moriuchi, H, Ogasawara, K, Woodward, DF, Okuda-Ashitaka, E, Watanabe, K, Ito, S, Koda, N, Toh, H

J Biol Chem 2008
20950588 Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Takei, S, Kawamura, N, Hosokawa, M, Shimada, A, Woodward, DF, Hasegawa-Ishii, S, Furukawa, A, Watanabe, K, Yoshikawa, K, Chiba, Y

Brain Res 2011
Participants
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Output
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as an event of
Catalyst Activity

oxidoreductase activity of FAM213B [cytosol]

Physical Entity
FAM213B [cytosol] (Homo sapiens)
Activity
oxidoreductase activity (GO:0016491)
Inferred From
PGH2 is reduced to PGF2a by Fam213b (Mus musculus)
Cross References
RHEA
Authored
Williams, MG  (2012-02-24)
Reviewed
Rush, MG  (2012-11-10)
Created
Williams, MG  (2012-03-14)
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