PGH2 is reduced to PGF2a by FAM213B

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TXN) are the proteins involved in the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Moriuchi et al. 2008, Yoshikawa et al. 2011). This reaction has been inferred from an event in mice. An additional way of achieving this reaction involves the protein aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS.

Literature References
PubMed ID Title Journal Year
18006499 Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily

Daiyasu, H, Moriuchi, H, Ogasawara, K, Woodward, DF, Okuda-Ashitaka, E, Watanabe, K, Ito, S, Koda, N, Toh, H

J Biol Chem 2008
20950588 Preferential localization of prostamide/prostaglandin F synthase in myelin sheaths of the central nervous system

Takei, S, Kawamura, N, Hosokawa, M, Shimada, A, Woodward, DF, Hasegawa-Ishii, S, Furukawa, A, Watanabe, K, Yoshikawa, K, Chiba, Y

Brain Res 2011
Catalyst Activity

thioredoxin peroxidase activity of FAM213B [cytosol]

Inferred From
Cite Us!