Reactome | PGH2 is reduced to PGF2a by AKR1C3

PGH2 is reduced to PGF2a by AKR1C3

Stable Identifier

R-HSA-2161549

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

H(+) + NADPH + prostaglandin H2 => NADP(+) + prostaglandin F2alpha

ReviewStatus

5/5

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Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is responsible for the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Suzuki-Yamamoto et al. 1999, Komoto et al. 2004, Komoto et al. 2006). There is an additional way of achieving this reaction involving the prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TRX).

Literature References

PubMed ID	Title	Journal	Year
14979715	Crystal structure of human prostaglandin F synthase (AKR1C3) Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F	Biochemistry	2004
16475787	Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost Komoto, J, Yamada, T, Watanabe, K, Woodward, DF, Takusagawa, F	Biochemistry	2006
10622721	cDNA cloning, expression and characterization of human prostaglandin F synthase Suzuki-Yamamoto, T, Nishizawa, M, Fukui, M, Okuda-Ashitaka, E, Nakajima, T, Ito, S, Watanabe, K	FEBS Lett	1999