PGH2 is reduced to PGF2a by AKR1C3

Stable Identifier
R-HSA-2161549
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Aldo-keto reductase family 1 member C3 (AKR1C3) aka PGFS is responsible for the reduction of prostaglandin H2 (PGH2) to prostaglandin F2alpha (PGF2a) (Suzuki-Yamamoto et al. 1999, Komoto et al. 2004, Komoto et al. 2006). There is an additional way of achieving this reaction involving the prostamide/prostaglandin F synthase, FAM213B and thioredoxin (TRX).

Literature References
PubMed ID Title Journal Year
16475787 Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost

Komoto, J, Yamada, T, Watanabe, K, Woodward, DF, Takusagawa, F

Biochemistry 2006
14979715 Crystal structure of human prostaglandin F synthase (AKR1C3)

Komoto, J, Yamada, T, Watanabe, K, Takusagawa, F

Biochemistry 2004
10622721 cDNA cloning, expression and characterization of human prostaglandin F synthase

Suzuki-Yamamoto, T, Nishizawa, M, Fukui, M, Okuda-Ashitaka, E, Nakajima, T, Ito, S, Watanabe, K

FEBS Lett 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
prostaglandin H2 endoperoxidase reductase activity of AKR1C3 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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