Reactome | FBLN5 [extracellular region]

FBLN5 [extracellular region]

Stable Identifier

R-HSA-2161278

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Fibulin-5, FBLN5_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O95967 EFEMP2

Expand all

External Reference Information

External Reference

UniProt:Q9UBX5 FBLN5

Gene Names

FBLN5, DANCE, UNQ184/PRO210

Chain

signal peptide:1-23, chain:24-448

Reference Genes

BioGPS Gene:10516 FBLN5

COSMIC (genes):FBLN5 FBLN5

CTD Gene:10516 FBLN5

dbSNP Gene:10516 FBLN5

ENSEMBL:ENSG00000140092 FBLN5

HGNC:3602 FBLN5

KEGG Gene (Homo sapiens):10516 FBLN5

Monarch:10516 FBLN5

NCBI Gene:10516 FBLN5

OMIM:604580 FBLN5

UCSC:Q9UBX5 FBLN5

Reference Transcript

RefSeq:NM_006329.3 FBLN5

Other Identifiers

10516

11743043_a_at

16795965

203088_at

3576751

3576762

3576766

3576767

3576768

3576771

3576774

3576775

3576793

3576794

3576795

3576797

3576800

3576804

3576805

3576806

3576807

7980908

A_24_P364591

GE55234

GO:0000122

GO:0001558

GO:0003674

GO:0005178

GO:0005198

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0006810

GO:0006950

GO:0007155

GO:0007160

GO:0008022

GO:0008150

GO:0008283

GO:0009058

GO:0016525

GO:0022607

GO:0030023

GO:0030198

GO:0031012

GO:0033690

GO:0034394

GO:0034641

GO:0040007

GO:0042803

GO:0043167

GO:0043226

GO:0045944

GO:0046903

GO:0048251

GO:0048646

GO:0048856

GO:0062023

GO:0070062

GO:0071953

GO:0098867

GO:2000121

ILMN_1664176

TC14001443.hg

g5453649_3p_at

Participant Of

hasComponent

Fibrillins:MFAP2,MFAP5:Tropoelastin aggregate [extracellular region]

input

Tropoelastin associates with microfibrils

hasMember

Fibulins [extracellular region]

Inferred To

si:dkey-234i14.3 [extracellular region] (Danio rerio)

FBLN5 [extracellular region] (Canis familiaris)

FBLN5 [extracellular region] (Danio rerio)

FBLN5 [extracellular region] (Dictyostelium discoideum)

FBLN5 [extracellular region] (Gallus gallus)

FBLN5 [extracellular region] (Sus scrofa)

thbd [extracellular region] (Danio rerio)

frac [extracellular region] (Drosophila melanogaster)

CT7856 [extracellular region] (Drosophila melanogaster)

Homologues of FBLN5 [extracellular region] (Danio rerio)

Homologues of FBLN5 [extracellular region] (Dictyostelium discoideum)

Homologues of FBLN5 [extracellular region] (Drosophila melanogaster)

fbln5 [extracellular region] (Danio rerio)

si:dkey-163f14.6 [extracellular region] (Danio rerio)

Fbln5 [extracellular region] (Mus musculus)

Fbln5 [extracellular region] (Rattus norvegicus)

BcDNA:RE64043 [extracellular region] (Drosophila melanogaster)

nid-1 [extracellular region] (Caenorhabditis elegans)

ltbp3 [extracellular region] (Danio rerio)

ltbp3 [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_006320.2

OpenTargets

ENSG00000140092

HPA

ENSG00000140092-FBLN5

GeneCards

Q9UBX5

Ensembl

ENSG00000140092, ENST00000342058, ENSP00000345008

PRO

Q9UBX5

Orphanet

16031

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95967 EFEMP2	1	EFEMP2 [extracellular region] (R-HSA-2161231)	0.611	3
UniProt:P15502 ELN	3	ELN(?-786) [extracellular region] (R-HSA-2514775) ELN(27-?) [extracellular region] (R-HSA-2514783) ELN [extracellular region] (R-HSA-1454880)	0.611	3
UniProt:P28300 LOX	3	LOX(22-417) [extracellular region] (R-HSA-2022071) LOX(22-168) [extracellular region] (R-HSA-2022074) LOX [extracellular region] (R-HSA-2022085)	0.573	2
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127)	0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:P32242 OTX1			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:Q7Z417 NUFP2			0.556	3
UniProt:Q15645 PCH2			0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P0DTD1-PRO_0000449627 REP			0.527	2

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