Reactome | abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine

abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine

Stable Identifier

R-HSA-2161195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Deamination of abacavir monophosphate to form carbovir monophosphate

ReviewStatus

5/5

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abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine

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Cytosolic ADAL (Adenosine DeAminase-Like) catalyzes the reaction of abacavir monophosphate and water to form carbovir monophosphate and cyclopropylamine. The active form of the enzyme is a protein monomer complexed with a zinc ion (Murakami et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
21755941	Adenosine deaminase-like protein 1 (ADAL1): characterization and substrate specificity in the hydrolysis of N(6)- or O(6)-substituted purine or 2-aminopurine nucleoside monophosphates Furman, PA, Sofia, MJ, Du, J, Bao, H, Murakami, E, Mosley, RT	J Med Chem	2011