20kDa HA fragments are translocated to lysosomes

Stable Identifier
R-HSA-2160906
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
lysosomal lumen, plasma membrane
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20kDa HA fragments are translocated to lysosomes
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The smallest fragments HYAL2 can generate are 20kDa (approximately 50 disaccharide unit) HA fragments. These fragments are internalized and delivered to lysosomes (Knudson et al. 2002, Erickson & Stern 2012) where another hyalurindase, HYAL1, can degrade them further.

Literature References
PubMed ID Title Journal Year
22216413 Chain gangs: new aspects of hyaluronan metabolism

Stern, R, Erickson, M

Biochem Res Int 2012
11827788 CD44-mediated uptake and degradation of hyaluronan

Knudson, CB, Knudson, W, Chow, G

Matrix Biol 2002
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Authored
Jassal, B  (2012-03-05)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2012-03-05)
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