In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).
Jedrzejas, MJ, Stern, R
Strobl, B, Lepperdinger, G, Kreil, G
hyalurononglucosaminidase activity of HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane]
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