Reactome | Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Stable Identifier

R-HSA-2160892

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).

Literature References

PubMed ID	Title	Journal	Year
16104017	Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis Jedrzejas, MJ, Stern, R	Proteins	2005
9712871	HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity Strobl, B, Lepperdinger, G, Kreil, G	J Biol Chem	1998