Reactome | Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Stable Identifier

R-HSA-2160892

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

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In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).

Literature References

PubMed ID	Title	Journal	Year
16104017	Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis Jedrzejas, MJ, Stern, R	Proteins	2005
9712871	HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity Strobl, B, Lepperdinger, G, Kreil, G	J Biol Chem	1998