Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments

Stable Identifier
R-HSA-2160892
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

In acidic conditions, hyaluronidase 2 (HYAL2), a membrane-anchored protein, hydrolyses high molecular weight HA into approximately 20kDa (50 disaccharide unit) fragments (Lepperdinger et al. 1998, Jedrzejas & Stern 2005).

Literature References
PubMed ID Title Journal Year
9712871 HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity

Lepperdinger, G, Strobl, B, Kreil, G

J Biol Chem 1998
16104017 Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis

Jedrzejas, MJ, Stern, R

Proteins 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hyalurononglucosaminidase activity of HA:HAR:HYAL2:SLC9A1:pCHP:Ca2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed