HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+

Stable Identifier
R-HSA-2160884
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
HYAL2 interacts with NHE1 to create an acidic environment
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Hyaluronidases are only active in acidic environments. HYAL2 can interact with the Na+-H+ exchanger (SLC9A1, NHE1) which can create an acidic microenvironment in the caveolae. Extracellular Na+ ions are exchanged for protons which creates the acidic conditions required for the activity of HYAL2 (Bourguignon et al. 2004). The interaction of calcineurin homologous protein 1 (CHP1) with SLC9A1 is essential for the maintenance of, or increasing, the pH sensitivity of SLC9A1 thus CHP1 can regulate SLC9A1 activity (Lin & Barber 1996, Pang et al. 2004, Mishima et al. 2007). CHP1 depletion in Xenopus oocytes results in a dramatic reduction (>90%) in the Na+-H+ exchange activity of SLC9A1 (Pang et al. 2001).

Literature References
PubMed ID Title Journal Year
11350981 Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers

Pang, T, Su, X, Wakabayashi, S, Shigekawa, M

J. Biol. Chem. 2001
15090545 CD44 interaction with Na+-H+ exchanger (NHE1) creates acidic microenvironments leading to hyaluronidase-2 and cathepsin B activation and breast tumor cell invasion

Bourguignon, LY, Singleton, PA, Diedrich, F, Stern, R, Gilad, E

J Biol Chem 2004
8901634 A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange

Lin, X, Barber, DL

Proc. Natl. Acad. Sci. U.S.A. 1996
15035633 Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements

Pang, T, Hisamitsu, T, Mori, H, Shigekawa, M, Wakabayashi, S

Biochemistry 2004
17050540 Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1

Mishima, M, Wakabayashi, S, Kojima, C

J. Biol. Chem. 2007
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