HYAL1 hydrolyses (HA)50

Stable Identifier
R-HSA-2160874
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
HYAL1 hydrolyses (HA)50
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the acidic environment of the lysosome, hyaluronidase 1 (HYAL1) is able to hydrolyse large 20kDa HA fragments (approximately 50 disaccharide units) to 800 Da fragments (2 disaccharide units).

Literature References
PubMed ID Title Journal Year
16104017 Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis

Jedrzejas, MJ, Stern, R

Proteins 2005
Participants
Input
Output
Participates
as an event of
Catalyst Activity

hyalurononglucosaminidase activity of HYAL1-like proteins [lysosomal lumen]

Physical Entity
HYAL1-like proteins [lysosomal lumen] (Homo sapiens)
Activity
hyalurononglucosaminidase activity (GO:0004415)
Orthologous Events
HYAL1 hydrolyses (HA)50 (Bos taurus)
HYAL1 hydrolyses (HA)50 (Caenorhabditis elegans)
HYAL1 hydrolyses (HA)50 (Canis familiaris)
HYAL1 hydrolyses (HA)50 (Danio rerio)
HYAL1 hydrolyses (HA)50 (Gallus gallus)
HYAL1 hydrolyses (HA)50 (Mus musculus)
HYAL1 hydrolyses (HA)50 (Rattus norvegicus)
HYAL1 hydrolyses (HA)50 (Sus scrofa)
HYAL1 hydrolyses (HA)50 (Xenopus tropicalis)
Authored
Jassal, B  (2012-03-05)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2012-03-05)
Cite Us!