The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerisation of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.
Olson, JS, Spicer, AP, McDonald, JA
Heldin, P, Yoshino, T, Briskin, MJ, Butcher, EC, Shyjan, AM
Yamaguchi, Y, Watanabe, K
hyaluronan synthase activity of HAS1,2,3 [plasma membrane]
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