Reactome | HAS1,2,3 mediate the polymerization of HA

HAS1,2,3 mediate the polymerization of HA

Stable Identifier

R-HSA-2160851

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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HAS1,2,3 mediate the polymerization of HA

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The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerization of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.

Literature References

PubMed ID	Title	Journal	Year
9083017	Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase Olson, JS, Spicer, AP, McDonald, JA	J Biol Chem	1997
8798544	Functional cloning of the cDNA for a human hyaluronan synthase Heldin, P, Yoshino, T, Briskin, MJ, Butcher, EC, Shyjan, AM	J Biol Chem	1996
8798477	Molecular identification of a putative human hyaluronan synthase Yamaguchi, Y, Watanabe, K	J Biol Chem	1996