Reactome | HAS1,2,3 mediate the polymerisation of HA

HAS1,2,3 mediate the polymerisation of HA

Stable Identifier

R-HSA-2160851

Type

Reaction [Polymerisation]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

HAS1,2,3 mediate the polymerisation of HA

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerisation of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.

Literature References

PubMed ID	Title	Journal	Year
9083017	Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase Olson, JS, Spicer, AP, McDonald, JA	J Biol Chem	1997
8798544	Functional cloning of the cDNA for a human hyaluronan synthase Heldin, P, Yoshino, T, Briskin, MJ, Butcher, EC, Shyjan, AM	J Biol Chem	1996
8798477	Molecular identification of a putative human hyaluronan synthase Yamaguchi, Y, Watanabe, K	J Biol Chem	1996