HAS1,2,3 mediate the polymerisation of HA

Stable Identifier
R-HSA-2160851
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerisation of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.

Literature References
PubMed ID Title Journal Year
8798544 Functional cloning of the cDNA for a human hyaluronan synthase

Shyjan, AM, Heldin, P, Butcher, EC, Yoshino, T, Briskin, MJ

J Biol Chem 1996
9083017 Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase

Spicer, AP, Olson, JS, McDonald, JA

J Biol Chem 1997
8798477 Molecular identification of a putative human hyaluronan synthase

Watanabe, K, Yamaguchi, Y

J Biol Chem 1996
Participants
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Catalyst Activity
Title
hyaluronan synthase activity of HAS1,2,3 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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