The integral membrane dual-action glycosyltransferase proteins hyaluronan synthases 1-3 (HAS1-3) (Shyjan et al. 1996, Watanabe & Yamaguchi 1996, Spicer et al. 1997 respectively) mediate the polymerisation of glucuronic acid (GlcA) with N-acetylglucosamine (GlcNAc) to form hyaluronan (HA). The resulting polymer has the arrangement [-4GlcA-1,3GlcNAc-]n and can be as large as 10 miilion Da.
Shyjan, AM, Heldin, P, Butcher, EC, Yoshino, T, Briskin, MJ
Spicer, AP, Olson, JS, McDonald, JA
Watanabe, K, Yamaguchi, Y
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