Tenascin-C (TN-C) and its isoforms are multidomain extracellular matrix (ECM) proteins that are believed to be involved in the regulation of stromal-epithelial interactions. Some of the interactions between TN-C and cells are mediated by integrins. Alpha8beta1 integrin interacts with the third FN type III repeats which contains an RGD sequence in tenascin-c.
Chiquet, M, Backus, C, Kypta, R, Muller, U, Varnum-Finney, B, Venstrom, K, Reichardt, LF
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