Reactome | Interaction of integrin alpha8beta1 with Tenascin-C

Interaction of integrin alpha8beta1 with Tenascin-C

Stable Identifier

R-HSA-216064

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Interaction of integrin alpha8beta1 with Tenascin-C

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Tenascin-C (TN-C) and its isoforms are multidomain extracellular matrix (ECM) proteins that are believed to be involved in the regulation of stromal-epithelial interactions. Some of the interactions between TN-C and cells are mediated by integrins. Alpha8beta1 integrin interacts with the third FN type III repeats which contains an RGD sequence in tenascin-c.

Literature References

PubMed ID	Title	Journal	Year
7541634	The integrin receptor alpha 8 beta 1 mediates interactions of embryonic chick motor and sensory neurons with tenascin-C Varnum-Finney, B, Venstrom, K, Muller, U, Kypta, R, Backus, C, Chiquet, M, Reichardt, LF	Neuron	1995