Reactome | IL4I1:FAD oxidises L-Phe to kPPV

IL4I1:FAD oxidises L-Phe to kPPV

Stable Identifier

R-HSA-2160492

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

H2O + L-phenylalanine + O2 => 3-phenylpyruvate + H2O2 + NH4(+), phenylalanine + H2O + O2 => phenylpyruvate + NH3 + H2O2

ReviewStatus

5/5

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Extracellular L-amino-acid oxidase (IL4I1) catalyzes the reaction of phenylalanine, water, and molecular oxygen to form keto-phenylpyruvate, ammonia, and hydrogen peroxide. IL4I1, inferred to form a complex with FAD, has L-amino acid oxidase activity and with a strong preference for phenylalanine. The enzyme, found both in lysosomes and secreted into the extracellular space, is produced in the body by myeloid and dedritic cells (Boulland et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
17356132	Human IL4I1 is a secreted L-phenylalanine oxidase expressed by mature dendritic cells that inhibits T-lymphocyte proliferation Lasoudris, F, Guiter, C, Moller, P, Marquet, J, Boulland, ML, Baia, M, Castellano, F, Leroy, K, Molinier-Frenkel, V, Gaulard, P, Copie-Bergman, C	Blood	2007