Collagen type I binds integrin alpha11beta1

Stable Identifier
R-HSA-216045
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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The integrin alpha11beta1 along with alpha1beta1, alpha2beta1 and alpha10beta1 are referred to as a collagen receptor subgroup of the integrin family. Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).
Literature References
PubMed ID Title Journal Year
11518510 alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells

Fougerousse, F, Grundstrom, G, Gullberg, D, Tiger, CF, Velling, T

Dev Biol 2001
12496264 alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens

Knight, CG, Puranen, JS, Johnson, MS, Heino, J, Farndale, RW, Gullberg, D, Kapyla, J, Pentikainen, OT, Tiger, CF, Zhang, WM

J Biol Chem 2003
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