Reactome | Collagen type I binds integrin alpha11beta1

Collagen type I binds integrin alpha11beta1

Stable Identifier

R-HSA-216045

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Collagen type I binds integrin alpha11beta1

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The integrin alpha11beta1 along with alpha1beta1, alpha2beta1 and alpha10beta1 are referred to as a collagen receptor subgroup of the integrin family. Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11518510	alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells Fougerousse, F, Grundstrom, G, Gullberg, D, Tiger, CF, Velling, T	Dev Biol	2001
12496264	alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens Knight, CG, Puranen, JS, Johnson, MS, Heino, J, Farndale, RW, Gullberg, D, Kapyla, J, Pentikainen, OT, Tiger, CF, Zhang, WM	J Biol Chem	2003