Reactome | Collagen type I binds integrin alpha11beta1

Collagen type I binds integrin alpha11beta1

Stable Identifier

R-HSA-216045

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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Collagen type I binds integrin alpha11beta1

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The integrin alpha11beta1 along with alpha1beta1, alpha2beta1 and alpha10beta1 are referred to as a collagen receptor subgroup of the integrin family. Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12496264	alpha 11beta 1 integrin recognizes the GFOGER sequence in interstitial collagens Zhang, WM, Kapyla, J, Puranen, JS, Knight, CG, Tiger, CF, Pentikainen, OT, Johnson, MS, Farndale, RW, Heino, J, Gullberg, D	J Biol Chem	2003
11518510	alpha11beta1 integrin is a receptor for interstitial collagens involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells Tiger, CF, Fougerousse, F, Grundstrom, G, Velling, T, Gullberg, D	Dev Biol	2001