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KLRC2 [plasma membrane]
Stable Identifier
R-HSA-2159807
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NKG2C, NKG2-C type II integral membrane protein, NKG2C_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 interacts with NKG2C (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
HLA-E:CD94:NKG2C:DAP12 [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
DAP12 signaling (Homo sapiens)
PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of DAP12 (Homo sapiens)
DAP12 receptors:DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of LAT by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
p85 regulatory unit of PI3K binds p-6Y-SYK (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Homo sapiens)
DAP12 receptors:p-Y91,Y102-DAP12 dimer [plasma membrane] (Homo sapiens)
DAP12 receptors [plasma membrane] (Homo sapiens)
CD94:NKG2C:HLA-E [plasma membrane] (Homo sapiens)
CD94:NKG2C [plasma membrane] (Homo sapiens)
KLRC2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P26717 KLRC2
Gene Names
KLRC2, NKG2C
Chain
chain:1-231
Reference Genes
BioGPS Gene:3822 KLRC2
COSMIC (genes):KLRC2 KLRC2
CTD Gene:3822 KLRC2
dbSNP Gene:3822 KLRC2
ENSEMBL:ENSG00000205809 KLRC2
HGNC:6375 KLRC2
KEGG:hsa:3822 KLRC2
Monarch:3822 KLRC2
NCBI Gene:3822 KLRC2
OMIM:602891 KLRC2
UCSC:P26717 KLRC2
Reference Transcript
RefSeq:NM_002260.3 KLRC2
Other Identifiers
11731848_s_at
11762954_at
16761359
206785_PM_s_at
206785_s_at
32287_s_at
32297_s_at
3444123
3444124
3444126
3444128
3444129
3444132
3444135
3444136
3444137
3444139
3444140
3444141
3444142
3444143
3444144
3444145
3444146
3444149
3444150
3822
7961182
A_23_P22232
GE55147
GO:0002223
GO:0002228
GO:0002250
GO:0002376
GO:0004888
GO:0005515
GO:0005886
GO:0006968
GO:0007165
GO:0009897
GO:0016020
GO:0023024
GO:0030246
GO:0032814
GO:0043235
GO:0043323
GO:0045087
GO:0045954
GO:0060089
GO:0062081
GO:0098542
GO:1990405
HMNXSV003027619
HMNXSV003029312
ILMN_1707328
ILMN_2059357
PH_hs_0028957
PH_hs_0031306
TC12003272.hg
X54867_s_at
g7108353_3p_s_at
Participates
as a component of
CD94:NKG2C [plasma membrane] (Homo sapiens)
Inferred To
LOC100523789 [plasma membrane]
(Sus scrofa)
LOC100140174 [plasma membrane]
(Bos taurus)
Homologues of KLRC2 [plasma membrane]
(Bos taurus)
Homologues of KLRC2 [plasma membrane]
(Canis familiaris)
Homologues of KLRC2 [plasma membrane]
(Mus musculus)
Homologues of KLRC2 [plasma membrane]
(Rattus norvegicus)
NKG2A [plasma membrane]
(Bos taurus)
KLRC1 [plasma membrane]
(Bos taurus)
Klrc1 [plasma membrane]
(Mus musculus)
Klrc1 [plasma membrane]
(Rattus norvegicus)
KLRC1-4 [plasma membrane]
(Bos taurus)
LOC513869 [plasma membrane]
(Bos taurus)
LOC119866326 [plasma membrane]
(Canis familiaris)
KLRC2 [plasma membrane]
(Bos taurus)
KLRC2 [plasma membrane]
(Canis familiaris)
KLRC2 [plasma membrane]
(Gallus gallus)
KLRC2 [plasma membrane]
(Rattus norvegicus)
Klrc2 [plasma membrane]
(Mus musculus)
Klrc3 [plasma membrane]
(Mus musculus)
Cross References
RefSeq
NP_002251.2
Guide to Pharmacology - Targets
3172
ENSEMBL
ENSP00000371327
,
ENST00000381902
OpenTargets
ENSG00000205809
HPA
ENSG00000205809-KLRC2
PRO
P26717
Pharos - Targets
P26717
GlyGen
P26717
PDB
2L35
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13241 KLRD1
1
KLRD1 [plasma membrane]
(R-HSA-2326854)
0.609
2
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