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L-selenocysteine-residue-GPX4(?-197) [cytosol]
Stable Identifier
R-HSA-2142826
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GPX4, Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, GPX4_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX4(?-197) [cytosol] (Homo sapiens)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX4(?-197) [cytosol] (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX4(?-197) [cytosol] (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX4(?-197) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36969 GPX4
Gene Names
GPX4
Chain
transit peptide:1-, chain:-197
Reference Genes
BioGPS Gene:2879 GPX4
COSMIC (genes):GPX4 GPX4
CTD Gene:2879 GPX4
dbSNP Gene:2879 GPX4
ENSEMBL:ENSG00000167468 GPX4
HGNC:4556 GPX4
KEGG:hsa:2879 GPX4
Monarch:2879 GPX4
NCBI Gene:2879 GPX4
OMIM:138322 GPX4
UCSC:P36969 GPX4
Reference Transcript
RefSeq:NM_001039847.2 GPX4
RefSeq:NM_002085.4 GPX4
Participates
as a candidate of
GPX1/2/4 [cytosol] (Homo sapiens)
as a member of
GPX1/2/4 [cytosol] (Homo sapiens)
Inferred To
gpx-7 [cytosol]
(Caenorhabditis elegans)
Gpx4 [cytosol]
(Mus musculus)
Gpx4 [cytosol]
(Rattus norvegicus)
L-selenocysteine-residue-GPX4(?-197) [cytosol]
(Gallus gallus)
L-selenocysteine-residue-GPX4(?-197) [cytosol]
(Plasmodium falciparum)
GPX4 [cytosol]
(Bos taurus)
GPX4 [cytosol]
(Canis familiaris)
GPX4 [cytosol]
(Sus scrofa)
Modified Residues
Name
L-selenocysteine residue at 73
Coordinate
73
PsiMod Name
L-selenocysteine residue
PsiMod Definition
A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification.
Cross References
Guide to Pharmacology - Targets
3239
OpenTargets
ENSG00000167468
ENSEMBL
ENSP00000483655
,
ENST00000354171
,
ENSG00000167468
,
ENSP00000346103
,
ENST00000611653
HPA
ENSG00000167468-GPX4
GeneCards
GPX4
PRO
P36969
Pharos - Targets
P36969
Orphanet
GPX4
PDB
8Q8N
,
6HN3
,
5H5Q
,
7U4K
,
7L8R
,
6ELW
,
7U4J
,
7U4M
,
7L8Q
,
7U4L
,
2OBI
,
2GS3
,
6HKQ
,
8Q8J
,
7U4I
,
7U4N
,
7L8L
,
7L8K
,
5H5S
,
5H5R
,
7L8M
HMDB Protein
HMDBP00829
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