Reactome | CBR1 [cytosol]

CBR1 [cytosol]

Stable Identifier

R-HSA-2142784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Carbonyl reductase (NADPH)1, CBR1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9Y478 PRKAB1

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External Reference Information

External Reference

UniProt:P16152 CBR1

Gene Names

CBR1, CBR, CRN, SDR21C1

Chain

initiator methionine:, chain:2-277

Reference Genes

BioGPS Gene:873 CBR1

COSMIC (genes):CBR1 CBR1

CTD Gene:873 CBR1

dbSNP Gene:873 CBR1

ENSEMBL:ENSG00000159228 CBR1

HGNC:1548 CBR1

Monarch:873 CBR1

NCBI Gene:873 CBR1

OMIM:114830 CBR1

UCSC:P16152 CBR1

Reference Transcript

Other Identifiers

11729715_a_at

11729716_s_at

11746036_s_at

11753301_a_at

11753302_s_at

11760235_a_at

11760236_at

16922477

209213_PM_at

209213_at

38773_at

3919786

3919787

3919788

3919791

3919792

3919793

3919794

3919795

3919796

3919798

8068401

873

A_14_P107766

A_23_P29046

A_33_P3284394

GE57495

GO:0003824

GO:0004090

GO:0005515

GO:0005737

GO:0005829

GO:0006629

GO:0006766

GO:0006805

GO:0008106

GO:0008211

GO:0016491

GO:0016616

GO:0016655

GO:0019371

GO:0030154

GO:0030855

GO:0042373

GO:0043226

GO:0047020

GO:0047021

GO:0050221

GO:0070062

GO:0160163

GO:1903561

GO:2000379

HMNXSV003018587

ILMN_1809003

J04056_at

PH_hs_0004964

PH_hs_0031394

TC21000148.hg

g12803380_3p_at

Inferred To

LOC100622246 [cytosol] (Sus scrofa)

cbr1.2 [cytosol] (Xenopus tropicalis)

CBR1 [cytosol] (Bos taurus)

CBR1 [cytosol] (Canis familiaris)

CBR1 [cytosol] (Gallus gallus)

CBR1 [cytosol] (Mus musculus)

CBR1 [cytosol] (Rattus norvegicus)

cbr1 [cytosol] (Danio rerio)

Cross References

ZINC - World Drugs

CBR1_HUMAN

Guide to Pharmacology - Targets

1383

ENSEMBL

ENSP00000434613, ENSP00000290349, ENST00000530908, ENST00000290349

OpenTargets

ENSG00000159228

ZINC - FDA approved

CBR1_HUMAN

ZINC - Substances

CBR1_HUMAN

ZINC - Biogenic

CBR1_HUMAN

ZINC target

P16152

PRO

P16152

GlyGen

P16152

PDB

4Z3D, 1WMA, 3BHM, 3BHJ, 2PFG, 3BHI

ZINC - Metabolites

CBR1_HUMAN

HPA

ENSG00000159228-CBR1

Pharos - Targets

P16152

ZINC - Predictions - Purchasable

CBR1_HUMAN

HMDB Protein

HMDBP00075

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75828 CBR3	1	CBR3 [cytosol] (R-HSA-8937409)	0.708	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.564	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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