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ALOX12 [cytosol]
Stable Identifier
R-HSA-2142768
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Arachidonate 12-lipoxygenase, 12S-type, LOX12_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Biosynthesis of specialized proresolving mediators (SPMs) (Homo sapiens)
Biosynthesis of DHA-derived SPMs (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Biosynthesis of DPA-derived SPMs (Homo sapiens)
Biosynthesis of DPAn-3 SPMs (Homo sapiens)
Biosynthesis of DPAn-3-derived maresins (Homo sapiens)
ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Biosynthesis of DPAn-6 SPMs (Homo sapiens)
ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Synthesis of Lipoxins (LX) (Homo sapiens)
ALOX12 oxidises LTA4 to LXA4/B4 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonic acid metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
Arachidonic acid is converted to 12-oxoETE by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15 (Homo sapiens)
ALOX12/15 [cytosol] (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
Synthesis of Hepoxilins (HX) and Trioxilins (TrX) (Homo sapiens)
Arachidonic acid is converted to HXA3/B3 by ALOX12 (Homo sapiens)
ALOX12:Fe2+ [cytosol] (Homo sapiens)
ALOX12 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18054 ALOX12
Gene Names
ALOX12, 12LO, LOG12
Chain
chain:1-663
Reference Genes
BioGPS Gene:239 ALOX12
COSMIC (genes):ALOX12 ALOX12
CTD Gene:239 ALOX12
dbSNP Gene:239 ALOX12
ENSEMBL:ENSG00000108839 ALOX12
HGNC:429 ALOX12
KEGG Gene (Homo sapiens):239 ALOX12
Monarch:239 ALOX12
NCBI Gene:239 ALOX12
OMIM:152391 ALOX12
UCSC:P18054 ALOX12
Reference Transcript
RefSeq:NM_000697.2 ALOX12
Other Identifiers
0006020471
11741457_a_at
16830238
207206_s_at
239
35124_at
3708162
3708165
3708166
3708167
3708168
3708169
3708170
3708171
3708172
3708173
3708175
3708176
3708177
3708179
3708180
3708181
3708182
3708183
3716528
8004221
A_14_P113106
A_14_P134615
A_23_P152906
A_23_P152909
GE80938
GO:0003674
GO:0004052
GO:0005506
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006629
GO:0006631
GO:0006950
GO:0007155
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0010628
GO:0010656
GO:0010942
GO:0016020
GO:0016165
GO:0016491
GO:0016702
GO:0016787
GO:0019369
GO:0019372
GO:0019395
GO:0033559
GO:0034440
GO:0040011
GO:0042383
GO:0042554
GO:0042592
GO:0042759
GO:0043065
GO:0043066
GO:0043167
GO:0043226
GO:0043280
GO:0043536
GO:0043651
GO:0044281
GO:0046872
GO:0047977
GO:0048661
GO:0048856
GO:0048870
GO:0050473
GO:0051121
GO:0051122
GO:0051213
GO:0051901
GO:0055114
GO:0061436
GO:0070062
GO:0071396
GO:0090331
GO:1901751
GO:1905956
GO:2001301
GO:2001303
GO:2001306
HMNXSV003048226
ILMN_1713731
M62982_at
PH_hs_0000160
TC17000081.hg
TC17002029.hg
g4502050_3p_a_at
Participates
as a component of
ALOX12:Fe2+ [cytosol] (Homo sapiens)
Inferred To
lipA [cytosol]
(Dictyostelium discoideum)
Alox12 [cytosol]
(Mus musculus)
Alox12 [cytosol]
(Rattus norvegicus)
Homologues of ALOX12 [cytosol]
(Dictyostelium discoideum)
alox12 [cytosol]
(Danio rerio)
ALOX12 [cytosol]
(Bos taurus)
ALOX12 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_000688.2
ZINC - World Drugs
LOX12_HUMAN
Guide to Pharmacology - Targets
1387
OpenTargets
ENSG00000108839
ZINC - Substances
LOX12_HUMAN
ZINC target
P18054
ZINC - Biogenic
LOX12_HUMAN
PRO
P18054
PDB
3D3L
ZINC - Metabolites
LOX12_HUMAN
IntEnz
1.13.11.31
,
1.13.11.33
GeneCards
P18054
HPA
ENSG00000108839-ALOX12
Ensembl
ENSP00000251535
,
ENSG00000108839
,
ENST00000251535
Pharos - Targets
P18054
ZINC - Predictions - Purchasable
LOX12_HUMAN
HMDB Protein
HMDBP00974
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02545 LMNA
3
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.508
4
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