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Synthesis of 12-eicosatetraenoic acid derivatives
Stable Identifier
R-HSA-2142712
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
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The 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoate (12-HpETE), 12-hydroxyeicosatetraenoate (12-HETE) and 12-oxo-eicosatetraenoate (12-oxoETE) are formed after the initial step of arachidonate oxidation by the arachidonate 12 and 15 lipoxygenases (ALOX12, ALOX12B and ALOX15 respectively). This part of the pathway is bifurcated at the level of 12S-hydroperoxy-eicosatetraenoate (12S-HpETE), which can either be reduced to 12S-hydro-eicosatetraenoate (12S-HETE) or converted to hepoxilins (Buczynski et al. 2009, Vance & Vance 2008).
Literature References
PubMed ID
Title
Journal
Year
Biochemistry of Lipids, Lipoproteins and Membranes, 5th Edition
Vance, JE
,
Vance, DE
2008
19244215
Thematic Review Series: Proteomics. An integrated omics analysis of eicosanoid biology
Dumlao, DS
,
Buczynski, MW
,
Dennis, EA
J Lipid Res
2009
Participants
Events
Arachidonate is oxidised to 12R-HpETE by ALOX12B
(Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4
(Homo sapiens)
ALOXE3 isomerises 12R-HpETE to HXA3
(Homo sapiens)
Arachidonate is oxidised to 12S-HpETE by ALOX12/15
(Homo sapiens)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4
(Homo sapiens)
Arachidonate is converted to 12-oxoETE by ALOX12
(Homo sapiens)
Participates
as an event of
Arachidonate metabolism (Homo sapiens)
Event Information
Go Biological Process
lipoxygenase pathway (0019372)
Orthologous Events
Synthesis of 12-eicosatetraenoic acid derivatives (Bos taurus)
Synthesis of 12-eicosatetraenoic acid derivatives (Caenorhabditis elegans)
Synthesis of 12-eicosatetraenoic acid derivatives (Canis familiaris)
Synthesis of 12-eicosatetraenoic acid derivatives (Danio rerio)
Synthesis of 12-eicosatetraenoic acid derivatives (Dictyostelium discoideum)
Synthesis of 12-eicosatetraenoic acid derivatives (Gallus gallus)
Synthesis of 12-eicosatetraenoic acid derivatives (Mus musculus)
Synthesis of 12-eicosatetraenoic acid derivatives (Plasmodium falciparum)
Synthesis of 12-eicosatetraenoic acid derivatives (Rattus norvegicus)
Synthesis of 12-eicosatetraenoic acid derivatives (Sus scrofa)
Synthesis of 12-eicosatetraenoic acid derivatives (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000106
Authored
Williams, MG (2012-02-24)
Reviewed
Rush, MG (2012-11-10)
Created
Williams, MG (2012-02-24)
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