Reactome | LTC4S [endoplasmic reticulum membrane]

LTC4S [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-2142692

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Leukotriene C4 synthase, LTC4S_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16873 LTC4S

Gene Names

LTC4S

Chain

chain:1-150

Reference Genes

BioGPS Gene:4056 LTC4S

COSMIC (genes):LTC4S LTC4S

CTD Gene:4056 LTC4S

dbSNP Gene:4056 LTC4S

ENSEMBL:ENSG00000213316 LTC4S

ENSEMBL:ENSG00000213316.10 LTC4S

ENSEMBL:ENSG00000283887.2 LTC4S

HGNC:6719 LTC4S

KEGG Gene (Homo sapiens):4056 LTC4S

Monarch:4056 LTC4S

NCBI Gene:4056 LTC4S

OMIM:246530 LTC4S

UCSC:Q16873 LTC4S

Reference Transcript

RefSeq:NM_145867.1 LTC4S

Other Identifiers

11729075_s_at

16993451

206480_PM_at

206480_at

2844462

2844463

2844465

2844468

2844470

2844471

2844473

2844474

2844475

2844476

39968_at

4056

8110562

GE80456

GO:0003824

GO:0004364

GO:0004464

GO:0004602

GO:0005515

GO:0005634

GO:0005635

GO:0005640

GO:0005783

GO:0005789

GO:0006629

GO:0006691

GO:0008047

GO:0008289

GO:0016020

GO:0016209

GO:0016491

GO:0016740

GO:0016829

GO:0019370

GO:0031965

GO:0042759

GO:0042802

GO:0043226

GO:0043231

GO:0098754

GO:0098772

GO:0098869

HMNXSV003023196

ILMN_1668247

TC05003417.hg

U50136_rna1_at

g4505040_3p_at

Participates

as a component of

LTC4S trimer [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

LTC4S [nuclear envelope]

Inferred To

Homologues of LTC4S [endoplasmic reticulum membrane] (Gallus gallus)

LTC4S [endoplasmic reticulum membrane] (Bos taurus)

LTC4S [endoplasmic reticulum membrane] (Canis familiaris)

LTC4S [endoplasmic reticulum membrane] (Danio rerio)

LTC4S [endoplasmic reticulum membrane] (Gallus gallus)

LTC4S [endoplasmic reticulum membrane] (Mus musculus)

LTC4S [endoplasmic reticulum membrane] (Rattus norvegicus)

LTC4S [endoplasmic reticulum membrane] (Sus scrofa)

mgst [endoplasmic reticulum membrane] (Dictyostelium discoideum)

LTC4SL [endoplasmic reticulum membrane] (Gallus gallus)

ltc4s.1 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_665874.1

Guide to Pharmacology - Targets

1391

OpenTargets

ENSG00000213316

HPA

ENSG00000213316-LTC4S

GeneCards

Q16873

ZINC target

Q16873

Ensembl

ENSG00000213316, ENSP00000492334, ENST00000639087, ENSP00000292596, ENSG00000283887, ENST00000292596

PRO

Q16873

Pharos - Targets

Q16873

HMDB Protein

HMDBP00807

PDB

4J7Y, 4JRZ, 4JC7, 3HKK, 3PCV, 5HV9, 2PNO, 4BPM, 2UUH, 6R7D, 4JCZ, 3LEO, 2UUI, 4WAB, 4J7T, 3B29

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14843 FFAR3	1	FFAR3 [plasma membrane] (R-HSA-443951)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	5
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3

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