Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
L-selenocysteine-residue-GPX2 [cytosol]
Stable Identifier
R-HSA-2142687
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glutathione peroxidase 2, GPX2_HUMAN, GPX2
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
TP53 Regulates Metabolic Genes (Homo sapiens)
GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Arachidonate metabolism (Homo sapiens)
Synthesis of 12-eicosatetraenoic acid derivatives (Homo sapiens)
12R-HpETE is reduced to 12R-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
12S-HpETE is reduced to 12S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
Synthesis of 15-eicosatetraenoic acid derivatives (Homo sapiens)
15S-HpETE is reduced to 15S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
Synthesis of 5-eicosatetraenoic acids (Homo sapiens)
5S-HpETE is reduced to 5S-HETE by GPX1/2/4 (Homo sapiens)
GPX1/2/4 [cytosol] (Homo sapiens)
GPX2 tetramer [cytosol] (Homo sapiens)
L-selenocysteine-residue-GPX2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18283 GPX2
Gene Names
GPX2
Chain
chain:1-190
Reference Genes
BioGPS Gene:2877 GPX2
COSMIC (genes):GPX2 GPX2
CTD Gene:2877 GPX2
dbSNP Gene:2877 GPX2
ENSEMBL:ENSG00000176153 GPX2
HGNC:4554 GPX2
KEGG:hsa:2877 GPX2
Monarch:2877 GPX2
NCBI Gene:2877 GPX2
OMIM:138319 GPX2
UCSC:P18283 GPX2
Reference Transcript
RefSeq:NM_002083.3 GPX2
Other Identifiers
11755276_a_at
16793877
202831_PM_at
202831_at
2877
35194_at
3568604
3568605
3568606
3568607
3568609
3568611
3568612
3568613
3568614
3568615
72993_s_at
7979658
A_23_P3038
GE81111
GO:0003824
GO:0004601
GO:0004602
GO:0005737
GO:0005829
GO:0006979
GO:0009055
GO:0016209
GO:0016491
GO:0043226
GO:0045171
GO:0047066
GO:0072686
GO:0098754
GO:0098869
ILMN_2133205
PH_hs_0030889
TC14001223.hg
X68314_at
g4504102_3p_at
Participates
as a component of
GPX2 tetramer [cytosol] (Homo sapiens)
Inferred To
GPX2 [cytosol]
(Canis familiaris)
Gpx2 [cytosol]
(Mus musculus)
Gpx2 [cytosol]
(Rattus norvegicus)
L-selenocysteine-residue-GPX2 [cytosol]
(Gallus gallus)
L-selenocysteine-residue-GPX2 [cytosol]
(Sus scrofa)
Modified Residues
Name
L-selenocysteine residue at 40
Coordinate
40
PsiMod Name
L-selenocysteine residue
PsiMod Definition
A protein modification that effectively converts a source amino acid residue to an L-selenocysteine, a natural pretranslational modification.
Cross References
ENSEMBL
ENST00000389614
,
ENSG00000176153
,
ENSP00000374265
OpenTargets
ENSG00000176153
IntEnz
1.11.1.9
GeneCards
GPX2
HPA
ENSG00000176153-GPX2
PRO
P18283
Pharos - Targets
P18283
HMDB Protein
HMDBP00833
PDB
2HE3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text