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p-S345-PARD6A [plasma membrane]
Stable Identifier
R-HSA-2134533
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-PARD6A
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
SMURF1 ubiquitinates RHOA (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
p-S345-PARD6A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NPB6 PARD6A
Gene Names
PARD6A, PAR6A
Chain
chain:1-346
Reference Genes
BioGPS Gene:50855 PARD6A
COSMIC (genes):PARD6A PARD6A
CTD Gene:50855 PARD6A
dbSNP Gene:50855 PARD6A
ENSEMBL:ENSG00000102981 PARD6A
ENSEMBL_homo_sapiens_GENE:ENSG00000102981.10 PARD6A
HGNC:15943 PARD6A
KEGG Gene (Homo sapiens):50855 PARD6A
Monarch:50855 PARD6A
NCBI Gene:50855 PARD6A
OMIM:607484 PARD6A
UCSC:Q9NPB6 PARD6A
Reference Transcript
RefSeq:NM_001037281.1 PARD6A
RefSeq:NM_016948.2 PARD6A
Other Identifiers
11715230_s_at
16820249
205245_PM_at
205245_at
3665724
3665725
3665728
3665732
3665733
3665734
37444_at
50855
7996647
A_14_P101481
A_23_P140821
GE58744
GO:0001726
GO:0001933
GO:0005515
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0005938
GO:0007010
GO:0007049
GO:0007098
GO:0007163
GO:0016020
GO:0016032
GO:0016324
GO:0030742
GO:0031267
GO:0034330
GO:0034451
GO:0036211
GO:0042995
GO:0043226
GO:0045197
GO:0045217
GO:0050714
GO:0051301
GO:0060341
GO:0070160
GO:0070161
GO:0120157
GO:1904781
HMNXSV003003699
ILMN_1654112
ILMN_2323848
PH_hs_0006209
TC16000544.hg
g8394416_3p_at
Participates
as a component of
PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
Other forms of this molecule
PARD6A [plasma membrane]
PARD6A [cytosol]
PARD6A [cell junction]
Inferred To
phospho-par-6 [plasma membrane]
(Caenorhabditis elegans)
phospho-par-6 [plasma membrane]
(Drosophila melanogaster)
Ghost homologue of p-S345-PARD6A [plasma membrane]
(Xenopus tropicalis)
phospho-pard6a [plasma membrane]
(Danio rerio)
phospho-Pard6a [plasma membrane]
(Mus musculus)
phospho-Pard6a [plasma membrane]
(Rattus norvegicus)
phospho-PARD6A [plasma membrane]
(Bos taurus)
phospho-PARD6A [plasma membrane]
(Canis familiaris)
phospho-PARD6A [plasma membrane]
(Gallus gallus)
phospho-PARD6A [plasma membrane]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 345
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001032358.1
,
NP_058644.1
OpenTargets
ENSG00000102981
GeneCards
Q9NPB6
HPA
ENSG00000102981-PARD6A
Ensembl
ENST00000458121
,
ENSG00000102981
,
ENSP00000219255
,
ENSP00000392388
,
ENST00000219255
PRO
Q9NPB6
Pharos - Targets
Q9NPB6
PDB
1WMH
HMDB Protein
HMDBP08500
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P41743 PRKCI
3
PRKCI [nucleoplasm]
(R-HSA-9021345)
PRKCI [cytosol]
(R-HSA-58206)
PRKCI [plasma membrane]
(R-HSA-420005)
0.949
17
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.906
10
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.755
7
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.508
2
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