TGFBR2 phosphorylates TGFBR1 and PARD6A

Stable Identifier
R-HSA-2134532
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cell junction, plasma membrane, extracellular region, cytosol
ReviewStatus
5/5
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TGFBR2 phosphorylates TGFBR1 and PARD6A
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TGFBR2 recruited to tight junctions after TGF-beta stimulation phosphorylates PARD6A on serine residue S345, and it also phosphorylates TGFBR1 (Ozdamar et al. 2005). This was inferred from experiments in which a recombinant mouse Pard6a and recombinant human TGFBR1 and TGFBR2 were used.
Literature References
PubMed ID Title Journal Year
15761148 Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

Barrios-Rodiles, M, Zhang, Y, Wrana, JL, Wang, HR, Bose, R, Ozdamar, B

Science 2005
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TGFBR2 phosphorylates Pard6a (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-02-24)
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