Reactome | PARD3:p-PARD6A:PRKCZ [cell junction]

PARD3:p-PARD6A:PRKCZ [cell junction]

Stable Identifier

R-HSA-2134528

Type

Complex

Species

Homo sapiens

Compartment

cell junction

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by TGFB family members (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex (Homo sapiens)
    - TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
      - Disassembly of tight junctions (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
      - SMURF1 binds phosphorylated PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
      - SMURF1 ubiquitinates RHOA (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)
      - TGFBR2 phosphorylates TGFBR1 and PARD6A (Homo sapiens)
        
        Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)
        
        PARD3:p-PARD6A:PRKCZ [cell junction] (Homo sapiens)

Participants

components

Participates

as a component of

Tight Junction Complex:p-PARD6A:RHOA [cell junction] (Homo sapiens)

Inferred To

PARD3:p-PARD6A:PRKCZ [cell junction] (Canis familiaris)

PARD3:p-PARD6A:PRKCZ [cell junction] (Danio rerio)

PARD3:p-PARD6A:PRKCZ [cell junction] (Drosophila melanogaster)

PARD3:p-PARD6A:PRKCZ [cell junction] (Mus musculus)

PARD3:p-PARD6A:PRKCZ [cell junction] (Rattus norvegicus)

PARD3:p-PARD6A:PRKCZ [cell junction] (Sus scrofa)